Below are several video clips of experts discussing MDS.
Chronic anaemia in MDS
Doctor David Valcárcel, University Hospital Vall d’Hebron
In this video, Dr Valcárcel outlines the incidence, symptoms and treatments of chronic anaemia in patients with MDS. Dr Valcárcel also describes the role of ineffective erythropoiesis in the pathogenesis of chronic anaemia in MDS
3-minute video
MDS biology and ineffective erythropoiesis
Professor Clara Camaschella, Professor of Internal Medicine and Haematology,
Vita-Salute San Raffaele University
In this video, Professor Camaschella describes MDS and the classification system, before defining ring sideroblasts and their contribution to ineffective erythropoiesis in MDS
3-minute video
The impact of transfusions and iron overload in MDS patients
Doctor David Valcárcel, University Hospital Vall d’Hebron
In this video, Dr Valcárcel outlines the risks associated with red blood cell transfusions in patients with MDS. Dr Valcárcel also describes the subsequent effect of iron overload and the impact of iron chelation therapy.
4-minute video
Below are several video clips of experts discussing topics related to MDS and β-thalassaemia.
Parallels in ineffective erythropoiesis: MDS and β‑thalassaemia biology
Professor Clara Camaschella, Professor of Internal Medicine and Haematology,
Vita-Salute San Raffaele University
In this video, Professor Camaschella discusses some of the growth factors and transcription factors involved in erythropoiesis. Professor Camaschella describes the role of GATA‑1 and the transforming growth factor (TBF‑β) superfamily in the erythropoiesis process and in the ineffective erythropoiesis that plays a key part in the chronic anaemia observed in MDS and β-thalassaemia.
6-minute video
Haematological diseases and iron overload
Professor Clara Camaschella, Professor of Internal Medicine and Haematology,
Vita-Salute San Raffaele University
In this video, Professor Camaschella describes how iron absorption is regulated during erythropoiesis and discusses the role of hepcidin, the central regulator of systemic iron homeostasis, before introducing the concept of iron loading anaemias and the mechanism of iron overload in β‑thalassaemia. Professor Camaschella then outlines the mechanisms and effect of iron overload in patients with MDS and highlights the similarities with β-thalassaemia
5-minute video
Mechanisms of erythropoiesis and erythroid homeostasis
Professor Olivier Hermine, Professor of Haematology,
Paris Necker Children’s Hospital
In this video, Professor Hermine outlines the mechanism of erythropoiesis and explains the importance of erythroid homeostasis, highlighting the regulatory hormones and transcription factors involved.
3-minute video
The role of GATA-1 in the regulation of erythropoiesis
Professor Olivier Hermine, Professor of Haematology,
Paris Necker Children’s Hospital
In this video, Professor Hermine provides an overview of the regulation mechanisms involved in erythropoiesis, outlining the role of GATA-1 and HSP70 in these processes. Professor Hermine also describes the mechanisms of ineffective erythropoiesis observed in several haematological disorders.
4-minute video
Differences and similarities of MDS and β‑thalassaemia
Doctor Esther Natalie Oliva, Haematologist, Grande Ospedale Metropolitano
Bianchi-Melacrino-Morelli
In this video, Doctor Oliva introduces MDS and β‑thalassaemia and the differences between the diseases. Doctor Oliva also discusses the differences and similarities in the treatment of both diseases.
3-minute video