Intended for healthcare professionals in the Belux only

Expert videos

MDS

Below are 6 videoclips

Current therapeutic approach for lower-risk MDS patients

Prof. Pierre Fenaux, Hematology and Immunology department, University hospitals Paris

2-minute video

Management of chronic anaemia in MDS

Doctor David Valcárcel, University Hospital Vall d’Hebron

In this video, Dr Valcárcel discusses the use of ESAs as treatment for chronic anaemia in MDS and outlines predictive factors for a response to such treatments. Dr Valcárcel also describes alternative therapies available for patients with MDS who do not respond to ESAs and the current research investigating novel therapies in this setting.

3-minute video

MDS biology and ineffective erythropoiesis

Professor Clara Camaschella, Professor of Internal Medicine and Haematology, Vita-Salute San Raffaele University

In this video, Professor Camaschella describes MDS and the classification system, before defining ring sideroblasts and their contribution to ineffective erythropoiesis in MDS.

3-minute video

Chronic anaemia in MDS

Doctor David Valcárcel, University Hospital Vall d’Hebron

In this video, Dr Valcárcel outlines the incidence, symptoms and treatments of chronic anaemia in patients with MDS. Dr Valcárcel also describes the role of ineffective erythropoiesis in the pathogenesis of chronic anaemia in MDS.

3-minute video

Managing chronic anaemia in MDS: Case study

Doctor David Valcárcel, University Hospital Vall d’Hebron

In this video, Dr Valcárcel presents a case study of a patient with anaemia who was diagnosed with MDS. Dr Valcárcel discusses the treatments and outcomes for this patient.

2-minute video

The impact of transfusions and iron overload in MDS patients

Doctor David Valcárcel, University Hospital Vall d’Hebron

In this video, Dr Valcárcel outlines the risks associated with red blood cell transfusions in patients with MDS. Dr Valcárcel also describes the subsequent effect of iron overload and the impact of iron chelation therapy.

4-minute video

β‑thalassaemia

Below are 18 videoclips

β‑thalassaemia biology and ineffective erythropoiesis

Professor Clara Camaschella, Professor of Internal Medicine and Haematology, Vita-Salute San Raffaele University

In this video, Professor Camaschella describes MDS and the classification system, before defining ring sideroblasts and their contribution to ineffective erythropoiesis in MDS.

3-minute video

Treatment of β‑thalassaemia

Professor Maria Domenica Cappellini, Professor of Internal Medicine, University of Milan

In this video, Professor Cappellini discusses the classification and treatment of transfusion-dependent and non-transfusion-dependent β‑thalassaemia.

7-minute video

Mechanisms of anaemia in β‑thalassaemia

Professor Maria Domenica Cappellini, Professor of Internal Medicine, University of Milan

In this video, Professor Cappellini focusses on the mechanisms of anaemia in β‑thalassaemia, describing the elements that contribute to ineffective erythropoiesis. Professor Cappellini also addresses the importance of ineffective erythropoiesis and the varying severity of the β‑thalassaemia.

4-minute video

Burden of anaemia and chronic transfusions

Professor Maria Domenica Cappellini, Professor of Internal Medicine, University of Milan

In this video, Professor Cappellini discusses the burden of chronic anaemia in patients with β-thalassaemia, including the varying impact of anaemia on transfusion-dependent and non-transfusion-dependent patients. Professor Cappellini also considers the impact of red blood cell transfusions on patients with β‑thalassaemia including the effect on their psychological wellbeing.

8-minute video

Iron overload

Professor Maria Domenica Cappellini, Professor of Internal Medicine, University of Milan

In this video, Professor Capellini describes the impact of iron overload on patient morbidity and explains how iron overload can be managed.

5-minute video

Iron chelation therapy

Professor Maria Domenica Cappellini, Professor of Internal Medicine, University of Milan

In this video, Professor Capellini discusses how the treatment of iron overload has evolved over the years and highlights the side effects of iron chelation therapy.

6-minute video

Complications of ineffective erythropoiesis in
β-thalassaemia

Professor Olivier Hermine, Professor of Haematology, Paris Necker Children’s Hospital

In this video, Professor Hermine describes several complications associated with ineffective erythropoiesis in patients with β-thalassaemia. Professor Hermine also outlines the mechanisms of iron overload due to ineffective erythropoiesis and as a result of red blood cell transfusions, highlighting the resulting complications experienced by patients with β-thalassaemia.

5-minute video

β-thalassaemia: Background and introduction

Professor Antonis Kattamis, Professor of Pediatric Hematology Oncology, Aghia Sophia Children’s Hospital

In this video, Professor Kattamis describes the pathogenic mechanism of ineffective erythropoiesis that leads to chronic anaemia in patients with β-thalassaemia. Professor Kattamis also outlines the classification and age distribution of patients with the disease.

6-minute video

β-thalassaemia: Treatment advancement and current goals

Professor Antonis Kattamis, Professor of Pediatric Hematology Oncology, Aghia Sophia Children’s Hospital

In this video, Professor Kattamis reflects on the β-thalassaemia treatment advancements over the years and outlines the current treatment goals for these patients.

4-minute video

Treatment of iron overload in patients with
β-thalassaemia

Professor Antonis Kattamis, Professor of Pediatric Hematology Oncology, Aghia Sophia Children’s Hospital

In this video, Professor Kattamis describes the complications associated with iron overload in patients with β-thalassaemia and provides a summary of the iron chelation therapies currently available.

3-minute video

Clinical complications of transfusion-dependent and non-transfusion-dependent β-thalassaemia

Professor Antonis Kattamis, Professor of Pediatric Hematology Oncology, Aghia Sophia Children’s Hospital

In this video, Professor Kattamis outlines the clinical presentation and complications associated with transfusion-dependent and non-transfusion-dependent β-thalassaemia. He also describes a number of difficulties these patients may face.

5-minute video

Chronic anaemia in β-thalassaemia

Professor Antonio Piga, Professor of Paediatrics, Hospital S.Luigi Gonzaga

In this video, Professor Piga describes the association between the genotype and the severity of anaemia in patients with β-thalassaemia. Professor Piga also outlines the mechanism of ineffective erythropoiesis in β-thalassaemia.

2-minute video

Management of chronic anaemia in β-thalassaemia

Professor Antonio Piga, Professor of Paediatrics, Hospital S.Luigi Gonzaga

In this video, Professor Piga outlines the use of red blood cell transfusions to treat anaemia in β-thalassaemia and the complications observed as a result of the subsequent iron overload. Professor Piga also highlights the iron chelation therapies available and the unmet need in β-thalassaemia.

7-minute video

Stem cell transplantation and gene therapy for the treatment of β-thalassaemia

Professor Antonio Piga, Professor of Paediatrics, Hospital S.Luigi Gonzaga

In this video, Professor Piga introduces stem cell transplantation and gene therapy for the treatment of β-thalassaemia, outlining the pros and cons associated with each procedure. Professor Piga also comments on the development of genome editing approaches.

4-minute video

β-thalassaemia: Epidemiology, aetiology and classification

Professor Ali Taher, Professor of Medicine at the Division of Hematology & Oncology, American University of Beirut Medical Center

In this video, Professor Taher outlines the epidemiology, aetiology and classification of β-thalassaemia. He also highlights the importance of β-thalassaemia prevention programmes.

5-minute video

β-thalassaemia: Iron overload

Professor Ali Taher, Professor of Medicine at the Division of Hematology & Oncology, American University of Beirut Medical Center

In this video, Professor Taher discusses iron overload associated with transfusion-dependent and non-transfusion-dependent β-thalassaemia and the development of iron chelation therapies.

5-minute video

Iron overload in patients with non-transfusion-dependent β-thalassaemia: Case study

Professor Ali Taher, Professor of Medicine at the Division of Hematology & Oncology, American University of Beirut Medical Center

In this video, Professor Taher presents the case study of a patient with non-transfusion-dependent β-thalassaemia who is experiencing iron overload and outlines the use of iron chelation therapy in such a patient.

4-minute video

Disease complications in patients with non-transfusion-dependent β-thalassaemia: Case study

Professor Ali Taher, Professor of Medicine at the Division of Hematology & Oncology, American University of Beirut Medical Center

In this video, Professor Taher presents the case study of a patient with non-transfusion-dependent β-thalassaemia, focusing on the comorbidities associated with the disease.

4-minute video

Other

Below are 5 videoclips

Parallels in ineffective erythropoiesis: MDS and β‑thalassaemia biology

Professor Clara Camaschella, Professor of Internal Medicine and Haematology, Vita-Salute San Raffaele University

In this video, Professor Camaschella discusses some of the growth factors and transcription factors involved in erythropoiesis. Professor Camaschella describes the role of GATA‑1 and the transforming growth factor (TBF‑β) superfamily in the erythropoiesis process and in the ineffective erythropoiesis that plays a key part in the chronic anaemia observed in MDS and β-thalassaemia.

6-minute video

Haematological diseases and iron overload

Professor Clara Camaschella, Professor of Internal Medicine and Haematology, Vita-Salute San Raffaele University

In this video, Professor Camaschella describes how iron absorption is regulated during erythropoiesis and discusses the role of hepcidin, the central regulator of systemic iron homeostasis, before introducing the concept of iron loading anaemias and the mechanism of iron overload in β‑thalassaemia. Professor Camaschella then outlines the mechanisms and effect of iron overload in patients with MDS and highlights the similarities with β-thalassaemia.

5-minute video

Mechanisms of erythropoiesis and erythroid homeostasis

Professor Olivier Hermine, Professor of Haematology, Paris Necker Children’s Hospital

In this video, Professor Hermine outlines the mechanism of erythropoiesis and explains the importance of erythroid homeostasis, highlighting the regulatory hormones and transcription factors involved.

3-minute video

The role of GATA-1 in the regulation of erythropoiesis

Professor Olivier Hermine, Professor of Haematology, Paris Necker Children’s Hospital

In this video, Professor Hermine provides an overview of the regulation mechanisms involved in erythropoiesis, outlining the role of GATA-1 and HSP70 in these processes. Professor Hermine also describes the mechanisms of ineffective erythropoiesis observed in several haematological disorders.

4-minute video

Differences and similarities of MDS and β‑thalassaemia

Doctor Esther Natalie Oliva, Haematologist, Grande Ospedale Metropolitano Bianchi-Melacrino-Morelli

In this video, Doctor Oliva introduces MDS and β‑thalassaemia and the differences between the diseases. Doctor Oliva also discusses the differences and similarities in the treatment of both diseases.

5-minute video